Tuesday, February 28, 2012

About CJC-1295




CJC-1295 was developed for clinical trials in the year 2000. The drug was originally synthesized to remove visceral fat deposits in AIDS patients. CJC 1295 was ultimately successful on all research subjects, as increasing the level of growth hormone in the body proved to increase fat loss.

Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection.

Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group.

Another very positive benefit of CJC-1295/CJC-1293 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening.

Sunday, February 26, 2012

About GHRP-6 (2)




GHRP-6 stands for “growth hormone releasing peptide”. As the name suggests, the product works by stimulating the body to release more Human Growth Hormone (HGH) and IGF-1. HGH and IGF-1 levels decline rapidly as one gets older, and it is this decline which is thought to be responsible for the aging process. Besides a much lower cost, GHRP-6 offers another distinct advantage over HGH injections as it does not shut down the body’s natural production of this hormone, it just enhances it.

Compared to GHRP-2, GHRP-6 is more attractive because at the recommended dosage it does not lead to desensitization and therefore diminishing effect over time as can happen with GHRP-2.

Possible benefits: Fat loss, muscle gain, increased strength, improved skin tone, better sleep, more energy, stronger bones and connective tissues.


Useful for: Bodybuilders looking to gain muscle; Ordinary people looking to lose fat; older persons looking for anti-aging benefits.
Use it before bed and/or post workout. Taken on an empty stomach (at least 2 hours since last meal), then wait at least 20-30 minutes after your injection before eating.
Works by subcutaneous injection into fat. It can be simultaneously injected in the same syringe as other peptides.

Description:
Growth Hormone Releasing Peptide-6 Synthetic is a single, non-glycosylated polypeptide chain containing 6 amino acids, having a molecular mass of 873 Dalton and a Molecular formula of C46H56N12O6.

Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.

Solubility:
It is recommended to reconstitute the lyophilized GHRP-6 in sterile 18MO-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

Thursday, February 23, 2012

About GHRP-6 (1)




In the world of bodybuilding, GHRP-6 is useful as it facilitates enhancements in terms of normal pulsatile physiological secretion by its hypothalamic action and pulsatile secretory bursts of GH. The list of benefits also include improved natural production of growth hormone, sound sleep, sense of well being, and fast healing of joints and tendons.

GHRP-6 stands for “growth hormone releasing peptide”. As the name suggests, the product works by stimulating the body to release more Human Growth Hormone (HGH) and IGF-1. HGH and IGF-1 levels decline rapidly as one gets older, and it is this decline which is thought to be responsible for the aging process. Besides a much lower cost, GHRP-6 offers another distinct advantage over HGH injections as it does not shut down the body’s natural production of this hormone, it just enhances it. 

This peptide has a strong effect on the body's release of GH. It almost promotes hunger and appetite by stimulating a release in Ghrelin which is a peptide in the stomach which promotes appetite and gastric emptying. GHRP-6 acts by stimulating the anterior pituitary gland which causes an increased released of GH. GHRP-6 is used for a range of medical issues including low natural GH production and to promote weight gain in abnormally thin individuals.

Wednesday, February 22, 2012

Melanotan (2)




To get a visibly flawless skin, you must know about this peptide as how it can provide you an exquisitely beautiful skin. Melanotan 1 is basically a synthetic derivative of its own natural counterpart called alpha-melanocyte-stimulating hormone (a-MSH).

The presence of two amino acids in the bodies natural a-MSH are converted in the production of Melanotan 1 increasing stability. The melanotropin peptides to a larger extent can influence pigmentation in the body. If melanotan peptide therapy is combined with UV-B light, it stimulates melanocytes production of melanin and specifically the production of eumelanin. Melanin works effectively in absorbing, reflecting and refracting light to preventing cellular damage in the skin. It also transforms cells to produce dark protective melanin which ultimately helps in reducing sun damage done to UV exposed skin. On the other hand, eumelanin is produced over pheomelanin pigment that after injecting offers greater tanning ability levels. However, melanotan only works when injected below the skin (subcutaneously).

Also known as afamelanotide, the half-life of Melanotan peptides is very short. It is being developed in implant form that contains control discharge effecting melanin density for dermatology use. From human lifestyle point of view, we can say that melanocortins can be one great revolution in cosmetic treatment including Botox, Viagra and much more. Although clinical trials are still going on to check the effectiveness of melanotan in bringing approved results to people.  Slight effects like nausea and flushing are common after taking subcutaneous injection of melanotan. There are specific skin types and accordingly the dose of Melanotan 1 is taken to get effective and safe results.

Tuesday, February 21, 2012

Melanotan (1)




Melanotan was initially created as a way to produce a organic tan base with no exposure to the sun. The original studies understood that the best method for preventing sunburns, sun-damage and skin cancer was a healthy, pure tan base. Since there are many skin types that are more likely to burn rather than tan, the analysises started to develop this peptide in an effort to create a safe way to create pure sun safety with a sunless tan.

Later, many study has expanded to determine it’s effectiveness as a treatment for sexual dysfunctions. This analysis commenced after the original trial, conducted at the college, found that three males who were taking the peptide found that the peptide not only had quick and noticeable tanning effects, but that the side effects included spontaneous erections. They also found there was a side effect of mild nausea.

The Melanotan peptide is being studied for its ability to improve and stimulate the production of Melanin in the skin. There are many potential uses for Melanotan, but the most pervasive and explorationed use is connected to providing safe, sunless tans. added researched effects also reveal that Melanotan can act as an aphrodisiac.

This distinct peptide generally works in starting a sunless tan by binding to the melanocortin receptors. This binding process causes responses that can impact pigmentation and sexual function. This process has also been shown in some studies, to effect energy and appetite.

Studies also indicate that the tanning effects that are potentially achievable via Melanotan can do more than realize cosmetic benefits. Individuals who are identified to burn easy or who have very fair skin can reduce the change of sun connected skin problems as the darker pigmentation of their skin helps shield from sun damage and skin cancer.

This versatile peptide is also being investigated for its effects on energy, appetite and libido. Earlier study has shown optimistic affect in all three regions and studies suggest it might provide benefits for athletes or individuals who are looking to increase their workout and health.

Monday, February 20, 2012

Melanotan II



Melanotan II was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, melanocyte stimulating hormone also plays an important role in regulating sexual arousal in men and women. 

Melanotan II has the additional effect of decreasing body fat mass. Melanotan II It is a cyclic lactyam analog of melanocyte stimulating hormone with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. Melanocortins (MCs) have been implicated in sexual function in animals.

A Melanocortins (MCs) analog, Melanotan II, can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, Melanotan II works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no undesirable side effects. The actions of the peptide were discovered accidentally while studying the effects of the peptide and related analogs on human skin pigmentation (tanning). (Hadley ME, 2005).

Sunday, February 19, 2012

Sermorelin (2)






Things to consider before using Sermorelin Acetate

Some medical conditions may interact with Sermorelin Acetate. Tell your doctor or pharmacist if you have any of the following medical conditions:

Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to sermorelin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pregnancy
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Thursday, February 16, 2012

Sermorelin (1)

Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues.

It stimulates the pituitary gland to naturally produce increased amounts of human growth hormone. Sermorelin Acetate is a truncated analog of a growth hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human growth hormone. The increased volume of human growth hormone (hGH) produced by the pituitary gland causes an increase in the production of Insulin-Like Growth Factor-1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient.

The purpose of adult Sermorelin growth hormone therapy is to reverse the effects of aging and secure the extensive treatment benefits described below.

The benefits of Sermorelin therapy or recombinant human growth hormone therapy include the following:

Tuesday, February 14, 2012

Oxytocin (3)



Scientists have discovered that the hormone oxytocin could help wallflowers overcome awkwardness in social situations
The chemical dubbed "the hormone of love" is known to increase empathy and bonding – especially parents and their children.
But now researchers have found it improves the social skills of the shy – but has little effect on those who are naturally confident.
The finding could have implications for those with severe social deficiencies, often apparent in conditions like autism.
Researchers at Israel's Seaver Autism Center for Research and Treatment and Columbia University were examining whether the hormone, which occurs naturally in the body could make us more understanding of others.

The scientists, whose research is published in Psychological Science, also measured the participants' social competency, using a test known as AQ which is usually used in autistic patients.
They found that oxytocin did improve powers of empathy – but only among those who were less socially proficient in the first place.
The more socially comfortable participants performed well on the empathetic task regardless of whether they were on oxytocin or placebo.
But less socially proficient participants performed significantly better on oxytocin, with their empathetic powers performance identical to that of the more outgoing participants.
(Richard Alleyne, http://www.telegraph.co.uk)

What should I discuss with my healthcare provider before using oxytocin?

Monday, February 13, 2012

Oxytocin (2)






How to increase Oxytocin levels
Ingestion of food triggers oxytocin release by activation of vagal afferent nerves. Most likely, it can also be released by stimulation of other senses such as olfaction, as well as by certain types of sound and light. In addition, purely psychological mechanisms can trigger the release of oxytocin. This means that positive interaction involving touch and psychological support may be health-promoting.

Oxytocin and sex
Also known as the "cuddle" hormone, oxytocin is released by both men and women at sexual orgasm.

Massage
Oxytocin can be released by various types of sensory stimulation, for example by touch and warmth. Bloodstream levels of oxytocin have been shown to rise during massage.

How it works
Oxytocin suppresses the activity of the brain region known as the amygdala, the area that processes fear and communicates it to the rest of the brain. A small sample group of 15 men inhaled either oxytocin or a placebo before performing a task in which they sorted pictures of angry or fearful faces and threatening scenes. During the test, the researchers monitored the subjects' brain activity with functional magnetic resonance imaging and found that the oxytocin group indeed had reduced activity in the amygdala.

Sunday, February 12, 2012

Oxytocin (1)




Oxytocin was discovered by a British pharmacologist named Henry Dale in 1909. It was first synthesised in 1953 by Vincent de Vigneaud, an American chemist who was awarded the 1955 Nobel Prize for Chemistry for this discovery, the first polypeptide hormone to be synthesised. He also synthesised the related hormone vasopressin, which controls the body's retention of water. Oxytocin is cys-tyr-ile-gln-asn-cys-pro-leu-glu, vasopressin is cys-tyr-phe-gln-asn-cys-pro-arg-glu.

Oxytocin (Greek, “quick birth”) is a mammalian hormone that also acts as a neurotransmitter in the brain.

In humans, oxytocin is thought to be released during hugging, touching, and orgasm in both sexes. In the brain, oxytocin is involved in social recognition and bonding, and may be involved in the formation of trust between people and generosity.

In women, it is released in large amounts after distension of the cervix and vagina during labor, and after stimulation of the nipples, facilitating birth and breastfeeding, respectively. Synthetic oxytocin is sold as medication under the trade names Pitocin and Syntocinon as well as generic oxytocin.


(excerpts of) Oxytocin hormone benefits and side effects by Ray Sahelian, M.D.

Oxytocin is a hormone that helps relax and reduce blood pressure and cortisol levels. Oxytocin increases pain thresholds, has anti anxiety effects, and stimulates various types of positive social interaction. In addition, it promotes growth and healing.

Thursday, February 9, 2012

Ipamorelin



Ipamorelin is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world. It is a synthetic peptide that has powerful Growth Hormone releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
Ipamorelin is a penta-peptide. (Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormone (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?

Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormone (GH) it creates allowing for maximum growth.

Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.In one experiment, various doses were administered over the course of 15 days to test the group's reactions.


There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.

Wednesday, February 8, 2012

GenF20




This product is based on HGH, which is the Human Growth Hormone.

Research shows that as we age, our levels of HGH decline. This decline is associated with wrinkles and laugh lines, as well as other more troubling signs of aging such as, decline in memory and focus, weakening bones, loss of interest in sex, weight gain and sluggish metabolism, lose of lean muscle tissue, and vision changes.

GenF20 Plus is a HGH releaser.

Essentially, this product encourages your body to release more HGH into your system. This blend of amino acids, peptides and nutrients are designed to launch your pituitary gland into action. The enteric coating on the GenF20 Plus ensures that the ingredients are not destroyed by your stomach acid before they can get into your bloodstream and do their job. It is believed that enteric coating increases absorption of medications by roughly 80%.

The advantages increased HGH level:
- Looked and feel younger
- Enjoy a greater sex drive
- Gain muscle tissue
- Lose fat
- Boosted metabolism
- More energy
- Increased immune system

This product contains a powerful antioxidant to rid the body of cancer cells.

Tuesday, February 7, 2012

Secratatropin



Secratatropin HGH is among the strongest legal HGH Releasers. Secratatropin HGH was initially designed to help professional athletes enhance their performance using herbal ingredients that imitate the results of Performance Enhancing Medicines.

Secratatropin HGH features all-natural ingredients like Alpha GPC, GABA, L-Arginine, L-Dopa Bean Extract, L-Glutamine, L-Isoleuncine, L-Tyrosine, L-Valine, L-Lysine, and L-Ornithine. Secratatropin HGH is 100% safe, 100% legal, and 100% effective.
People want the strength of prescriptions available in products you can purchase on your own. Secratatropin-HGH is a controversial and effective product for the public. Boosting your levels of HGH, which Secratatropin-HGH attempts, should help you with smooth skin, reduced fat storage, elevated energy and vitality. The active ingredients in this product stimulate your pituitary gland to generate more HGH naturally, which can have a plethora of results reaching from better exercises or helping you look youthful. Sectratatopin-HGH could be the fountain of youth.

Monday, February 6, 2012

IGF-1



IGF-1 isn't a top-secret chemical, nor is it a dangerous steroid. IGF1 is actually a natural molecular structure similar to insulin. IGF-1 is the abbreviation for Insulin-Like Growth Factor 1.Know in scientific circles as a polypeptide protein hormone, IGF-1 or Insulin-like Growth Factor 1 plays a vital role in childhood growth and stimulates anabolic effects (muscle building) in adults.

The primary purpose of IGF-1 is to stimulate cell growth. Every cell in the human body can be affected by IGF-1, but cells in muscle, cartilage, bone, liver, kidney, skin tissue, lungs, and nerves tend to be most positively affected.

There are 70 inter-connected amino acids that make up a single chain of IGF-1. IGF-1 is a hormone that is produced when the liver is stimulated by human growth hormone. When levels of HGH rise in the blood, the liver responds by producing more IGF-1. These higher "bursts" spur growth and regeneration by the body's cells, especially in muscle cells. Increases in IGF-1 levels have shown positive effects on increases in muscle strength, size, and efficiency. When you do not have enough IGF-1 in your body, whether caused by disease, malnutrition or a hormone imbalance, your growth can be stunted.

Several scientific tests have been conducted to determine the benefits of IGF-1 and thus have prompted companies to seek approval from the Federal Drug and Administration for substances that can increase the body's IGF-1 levels. Taken responsibly over time, products that increase IGF-1 can help improve muscularity and healing and recovery times. IGF-1 can also stimulate a decrease in body fat, an increase in lean muscle mass, improved skin tone and restful sleep. IGF-1 has also been documented to increase the rate and extent of muscle repair after injuries or strains. Not only do muscles recover more quickly, they also tend to return stronger and healthier than ever when levels of IGF-1 in the bloodstream are at their highest.

Thursday, February 2, 2012

HGH Spray




The Human Growth Agent (HGA) Spray is a combination of herbs and amino acids. Amino acids are one of the central chemicals needed by the body to function well. They are the building blocks of proteins and serve as intermediates in protein metabolism.

The Advantages of HGH Sprays

There are many different ways to supplement your body with HGH. You can take injections, pills or an effervescent drink mix (usually in the form of a powder). But none of these options are as effective as an HGH spray. When you use an HGH oral spray, you benefit from:

-         Faster absorption - Most other types of supplements need to pass through your stomach and liver first before they get into your blood stream. Oral sprays get absorbed through the lining of the mouth and can start working almost immediately.

Wednesday, February 1, 2012

CJC-1295




CJC-1295 is a long-acting GHRH analog and stimulates GH and IGF-1 secretion. It will keep a steady increase of HGH and IGF-1 with no increase in prolactin. [1] CJC-1295 represents a very exciting new compound that has the potential to increase growth hormone and IGF-I secretion and effects, with a built-in safeguard (the feedback effects of IGF-I) to limit excessive elevations of GH and IGF-1 levels. Intense fat loss. Increases protein synthesis for more muscle growth. GHRHKO animals receiving daily doses of CJC-1295 exhibited normal body weight and length. Mice treated every 48 and 72 h reached higher body weight and length than placebo-treated animals, without full growth normalization.



Sequence: Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-(Maleimidopropionyl)-NH2

Formula: C164H266N47O46

Growth Hormone Releasing Peptide (GHRP-6)





GHRP-6 (Growth Hormone Releasing Peptide – 6) is a 28-amino-acid peptide that signals the human body to begin secreting growth-hormone (GH). Growth Hormone in the human body has host of beneficial effects such as decreased body fat, increased muscle, and increased strength and stamina. The Growth Hormone secreted by the body then causes the liver to secrete the highly anabolic hormone known as IGF-1. IGF-1 also contributes greatly to the body’s ability to burn fat and build muscle. Thus, in several studies, when subjects were given GHRP-6, their muscle mass increased and their body fat was reduced significantly.

Both Growth Hormone as well as IGF-1 also has several beneficial effects on collagen and bone tissue growth, and it would be expected that by using GHRP-6, users would experience the full spectrum of benefits typically seen with the use of GH and possibly the concurrent use of both GH and IGF-1.

In several studies done in both humans and rodents, it has further been found that GHRP-6 has a rapid effect on Ghrelin. Ghrelin would appear to be involved in excess weight gain, adiposity, and insulin resistance. This occurs during both high fat as well as high carbohydrate diets.GHRP-6 is a Ghrelin antagonist, meaning that it actually fights against Grehlin in the human body, and this may be one possible mechanism by which it helps to reduce bodyfat. 

Bremelanotide (PT-141)





Bremelanotide (PT-141) was developed from Melanotan 2 (MT-II). PT-141 is a metabolite of MT-II that lacks the C-terminal amide function-stripping away tanning properties.


PT-141 is the only synthetic aphrodisiac. Studies have shown Bremelanotide to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications (PDE5s), PT-141 does not act upon the vascular system, but directly through the nervous system (hypothalamus) to increase desire. Viagra, Cials and Levitra are not considered aphrodisiacs as they do not have any direct effect on the libido. However, treatment with PDE5 inhibitors and PT-141 are known to have a synergistic effect.

Bremelanotide is a melanocortin peptide hormone. PT-141 binds to the melanocortin 4 receptor (MC4R) in particular in the brain. Nine out of ten volunteers experienced sexual arousal in trials. The aphrodisiac effects of Bremelanotide are in a class of its own. 

Bremelanotide, injected (subcutaneously), has a unique window of opportunity lasting six to 72 hours. In lab trials female rats exposed to PT-141 began "flirting" with male rats for sex. Postures and movements left no doubt in the male rats minds that they were in the mood. 

How to use Melanotan?




Melanotan and Melanotan II are supplied in vials as powders that need to be mixed with bacteriostatic water for injection. The Melanotan and Melanotan II powder are best stored in a freezer due to their slow degradation at room temperature, and are often shipped in ice packs for this reason. The degrading process is slow, so if your Melanotan did not get shipped in ice packs it will not make your batch that less effective as long as the exposure to the higher temperature has not exceeded several days.
As previously stated, Melanotan needs to be mixed with bacteriostatic water prior to injection. To achieve a concentration of 10mg/8ml, use 8ml of bacteriostatic water in your 10mg vial of powder. From this we can have a concentration level of 0.25mg per 0.2ml. This should be enough liquid for you to accurately draw up using a 1ml marked syringe, although you could choose your own concentration level using a similar process. By using a 1ml syringe we can successfully attach and detach needles, and store the solution filled syringe in the fridge ready for the next injection.
The dosages of Melanotan are greater then that of Melanotan II. A daily dosage of 2-3mg of Melanotan will bring about fruitful results, and a daily dosage of 1mg will do the same for Melanotan II. To restrict the undesirable side effects it is often best to start the dosages at a level of 1-1.5mg for Melanotan and 0.25mg-0.5mg for Melanotan II, and build the dosages by .25mg each day until the target dosage is reached.

The injection itself is done into the sub-cutaneous layer.

Both MT and MT II can be used for extended periods, whereby there is an initial daily administration of perhaps 2-3 weeks or until desired level of pigmentation has been achieved, followed by a maintenance phase of two injections per week.

About Melanotan




Melanotan (MT) and Melanotan II (MT-II) are both analogs of the alpha-melanocyte stimulating hormone (α-MSH) which is produced within the pituitary gland. Along with other melanocortins, they are responsible for various internal human functions including skin and hair pigmentation, appetite, libido and physical sexual arousal. Whilst these effects have been observed in both sexes, it is worth noting that increases in libido and sexual function are exclusive to MT-II.
Prompted by ultraviolet (UV) exposure, α-MSH release consequently stimulates production of melanin from the melanocytes within the skin. Melanin, as I'm sure you are aware, is a brown pigment and responsible for the tanning of the skin. Simply put, more α-MSH means more melanin, resulting in greater skin pigmentation. Since bodybuilding is such an aesthetic pursuit, and with darker skin that accentuates muscularity, it's little wonder that these drugs are in such high demand.

Melanotan may refer to one of two separate peptides:
Afamelanotide, originally developed under the names "Melanotan-1" or "Melanotan I" for skin tanning, a drug currently in trials in implant form as a prophylactic treatment for a series of light affected skin disorders and potential skin cancer preventative agent
Melanotan II, a drug originally developed as a skin tanning agent, but subsequently investigated as a potential treatment for sexual dysfunction.

While Melanotan is a straight, full length peptide, Melanotan II is a shortened, circular version of the afamelanotide peptide. While both Melanotan and Melanotan II have a tanning effect, there are some more side effects reported by users of MT II. Libido enhancement and spontaneous erections are surprising side effects of MT II that have been reported by the users.
MT causes tanning without any side effects and hence it is considered to better of the two peptides. But because the amino acid sequence is shorter in MT II, there are more MT II peptide chains available as compared to MT. Another major difference between MT and MT II is that MT II is cheaper than MT and this lures people to go for it rather than MT.
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