Monday, February 20, 2012

Melanotan II



Melanotan II was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, melanocyte stimulating hormone also plays an important role in regulating sexual arousal in men and women. 

Melanotan II has the additional effect of decreasing body fat mass. Melanotan II It is a cyclic lactyam analog of melanocyte stimulating hormone with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. Melanocortins (MCs) have been implicated in sexual function in animals.

A Melanocortins (MCs) analog, Melanotan II, can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, Melanotan II works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no undesirable side effects. The actions of the peptide were discovered accidentally while studying the effects of the peptide and related analogs on human skin pigmentation (tanning). (Hadley ME, 2005).

Melanotan II, PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects and to patients with erectile dysfunction (ED) who report an inadequate response to Viagra. The erectile response induced by PT-141 was statistically significant at both doses. PT-141 was safe and well tolerated in both studies. 

The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base. (Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB, 2004).

In addition to the sexual enhancement and tanning effects of Melanotan II, it has also exhibited the potential to decrease body fat mass and reduce food intake. (Choi YH, Li C, Hartzell DL, Lin J, Della-Fera MA, Baile CA, 2003).

Melanotan II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection. The recommended single Melanotan II dose for future Phase I studies is 0.025 mg/kg/day.

Increases sexual desire and function for men and women:
 - Minimal or no undesirable side effects.
- Decrease body fat mass and reduce food intake.
- Induces skin tanning at low doses.
- Potent self-tanner applications.


10 comments:

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  4. Melanotan II was developed by researchers at the University of Arizona College of Medicine.

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  5. Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. Melanocortins (MCs) have been implicated in sexual function in animals.

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    People who have used Melanotan have experienced various types of nausea and facial flushing. Melanotan 2 peptide also causes side- effects like freckles and aching erections. Several researchers have stated that Melanotan 2 should be taken in correct dose and received from a quality supplier in order to prevent any kind of side-effects. Melanotan 2 UK does not cause any kind of side-effect that is harmful for a user.

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  8. This peptide has also other side effects such as freckles in users who even don’t spend time in the sun exposure. People suffer with darkening of freckles while using Buy Melanotan 2 uk however these freckles fainter after some use of this medicine and disappear but soon these unnoticeable freckles become darker that makes them to be visible that new freckles have been produced. The side-effects are over after ceasing the use of this peptide. As soon as good tanning is received, the freckles disappear.
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