CJC-1295

CJC-1295 is a long-acting GHRH analog and stimulates GH and IGF-1 secretion. It will keep a steady increase of HGH and IGF-1 with no increase in prolactin. [1] CJC-1295 represents a very exciting new compound that has the potential to increase growth hormone and IGF-I secretion and effects, with a built-in safeguard (the feedback effects of IGF-I) to limit excessive elevations of GH and IGF-1 levels. Intense fat loss. Increases protein synthesis for more muscle growth. GHRHKO animals receiving daily doses of CJC-1295 exhibited normal body weight and length. Mice treated every 48 and 72 h reached higher body weight and length than placebo-treated animals, without full growth normalization.

Sequence: Tyr-DAla-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-(Maleimidopropionyl)-NH2

Formula: C164H266N47O46

Description: CJC-1295 is a long-acting version of GHRH (Growth Hormone Releasing Hormone) which has had its half life extended to 8 days. This is convenient as it means the product only needs to be injected 1-2 times per week for continuously elevated levels of Human Growth Hormone (HGH) and IGF-1. The advantage of using CJC-1295 instead of actual HGH injections is that injecting HGH shuts down the body's own natural production and therefore when injections are ceased, the body’s ability to produce it's own HGH may be impaired and take some time to recover. Since CJC-1295 only stimulates the body's own HGH production, this risk is not apparent.

Possible benefits: Fat loss, muscle gain, increased collagen and reduced wrinkles, increased bone density, strengthened immune system, increased energy.

Dosage: 0.5mg (500mcg) taken 1-2 times per week.

Doses per vial: 4 x 0.5mg doses (2 weeks worth)

When: Before bed on an empty stomach.

How: Subcutaneous injection into fat. It can be simultaneously injected in the same syringe as other peptides.

Water to mix: Add 1ml (100 units) of sterile solution to the vial. Every 500mcg is then equal to 0.25ml (25 units).

Best combined with: GHRP-6

Useful for: Those looking for anti-aging benefits, improved physique and sense of well being. 

CJC-1295 is a derivative of human GH-releasing factor1-29(HGRF1-29). HGRF1-29 is a naturally occurring peptide that is actually a truncated form of a larger peptide that binds to the growth hormone secretagogue receptor (GHS-R) and causes the release of growth hormone. CJC-1295 has four amino acids substituted in its chain that result in strong binding to serum albumin and prolong its half-life in the body. A single subcutaneous (sc) injection results in measurable quantities of CJC-1295 in the blood for up to 13 days. Additionally, a single dose of 60 ug/kg of CJC-1295 results in elevated levels of growth hormone (125%) while the pulsatile secretion of GH is maintained. Furthermore, 60 ug/kg of CJC-1295 elevated IGF-1 levels to the upper limit of normal. A dose of 30 ug/kg of CJC-1295 given weekly maintained its response with no evidence of desensitization.

CJC-1295 is currently being utilized by bodybuilders. A dose of 30 ug/kg equates to 3 mg per week for a 100 kg (220 lb) man and of course this would be doubled for a dose of 60 ug/kg. At these doses it may be cost prohibitive. Some are injecting CJC-1295 daily or even multiple times per day. There may be a danger of desensitization with frequent dosing. Many report seeing little gain with CJC-1295. This may be due to the fact that increasing plasma IGF-1 does not necessarily correlate with increased muscle mass due to changes in IGF binding proteins that may reduce the muscle-building activity of IGF-1. The “lack” of gains may also be due to users expecting AAS-like gains. Since CJC-1295 does not load water but results in lean gains as well as fat loss, large increases in scale weight should not be expected.